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Two protesters were injured in clashes with police during Tuesday's march against recent incidents of police brutality in New York City, an activist with the Stop Mass Incarceration network told Sputnik on Wednesday.

Stop Mass Incarceration called a nationwide demonstration to protest "the injustice of mass incarceration and police brutality" after the recent shooting of an unarmed black man by a white New York City Police Department (NYPD) officer.

"We had two people in the hospital last night. One of the protesters, who was arrested, was taken to hospital by the ambulance, and another person was injured with broken ribs due to NYPD, and she was not arrested," said Debra Sweet, of the World Can't Wait group with the New York-based network.

Sweet said 10 protesters in New York and 20 in Los Angeles were still in police custody Wednesday. She added these two rallies were the largest, attracting thousands of protesters, while Chicago, San Francisco, Seattle and Atlanta saw people turn up in hundreds.

In New York, crowds marched from Union Square to City Hall and the NYPD headquarters. They managed to block traffic on the Brooklyn Bridge and clashed with police. Several officers were reportedly attacked.

Sweet said that New York Mayor Bill de Blasio issued a statement earlier on Wednesday, saying NYPD was going to investigate any activities by the protesters during the rally.

"What about investigating many instances in New York when the police were killing unarmed people?" she asked.

In Los Angeles, protesters shut down parts of the city as they marched to the local Police Department headquarters. Sweet said Los Angeles police arrested 20 people, and her organization was told they may not get out until Thursday.

Those who were held in Atlanta and San Francisco have been set free, Sweet added, and there are reports they had been charged with violation of Administrative Code, rather than crime.

In recent months, the United States has seen a wave of mass protests against police brutality prompted by several killings of primarily unarmed African-American men by white police officers.

The most recent documented incident happened on April 4 when NYPD lawman Michael Slager shot 50-year-old Walter L. Scott in the back as he tried to run from a traffic police officer.