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Gunmen have attacked a bus carrying Coptic Christians in Egypt, killing more than 20 people and wounding dozens, Al Jazeera reports citing the state media.

The bus came under fire on Friday while travelling on the road to the St. Samuel Monastery in the Minya province, about 220km south of the capital, Cairo, health officials said.

The interior ministry said at least 26 people were killed and 25 wounded in the attack.

A ministry spokesman said security chiefs had arrived at the scene of the attack and had cordoned off the area. There was no immediate claim of responsibility.

Egypt's Christian minority, which makes up about 10 percent of the country's population, has repeatedly been targeted by armed groups. In April, at least 45 people were killed and more than 100 wounded in two separate suicide bomb attacks on churches in the cities of Tanta and Alexandria during Palm Sunday ceremonies.