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Meghan, the Duchess of Sussex, has accused Buckingham Palace of "perpetuating falsehoods" against her and husband Prince Harry in an explosive clip from an interview with Oprah Winfrey that is due to be aired on Sunday, CNN reports.

In the clip released on Wednesday night, Winfrey asks Meghan: "How do you feel about the palace hearing you speak your truth today?"

Meghan then says: "I don't know how they could expect that after all of this time, we would still just be silent if there is an active role that the firm is playing in perpetuating falsehoods about us.

"And, if that comes with risk of losing things, I mean ... there is a lot that has been lost already."

The firm is a term sometimes used to refer to the royal family. Buckingham Palace said it had "no comment" when asked about the interview clip.

The full interview conducted by Winfrey with Meghan and Prince Harry will air on CBS on Sunday and on UK channel ITV on Monday. It is their first sit-down appearance since leaving Britain for North America last year.

The couple announced in January 2020 that they were stepping back as working members of the royal family and moved to North America soon afterward. Buckingham Palace confirmed last month that they had agreed with Queen Elizabeth II, Harry's grandmother, that they would not be returning as working royals.

The move sparked talk of a rift between the couple -- who are settled in California and expecting their second child -- and the British royal family.