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Dozens of passengers were killed and several others injured after a train collision in southern Pakistan on Monday morning, CNN reported.

The Sir Syed Express train collided with the Millat Express train in Sindh province between railway stations, according to railway officials.

At least 45 people are dead and officials are working to rescue at least 17 people who remain trapped, Edhi Rescue Services said. So far, 23 people have been rescued.

Pakistani Prime Minister Imran Khan tweeted condolences for the victims of Monday's train crash and said that he was ordering a comprehensive investigation into railway safety.

"Shocked by the horrific train accident at Ghotki early this morning leaving 30 passengers dead," Khan tweeted, adding that he had asked the Railway Minister to ensure the injured received medical attention and the families of the dead received support.

Pakistan's railway system has a poor safety record, with a series of deadly accidents in recent years a tragic reminder of the country's ageing infrastructure and safety standards.