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Pope Francis was hospitalized with a respiratory infection Wednesday after experiencing difficulty breathing in recent days and will remain in the Rome hospital for several days of treatment, AP reported, citing the Vatican.

The 86-year-old pope, who had part of one lung removed as a young man, doesn’t have COVID-19, spokesman Matteo Bruni said in a statement late Wednesday.

The hospitalization was the first since Francis spent 10 days at the Gemelli hospital in July 2021 to have 33 centimeters (13 inches) of his colon removed.

It immediately raised questions about Francis’ overall health, and his ability to celebrate the busy Holy Week events that are due to begin this weekend with Palm Sunday.

Bruni said Francis had had trouble breathing in recent days and went to the Gemelli hospital Wednesday for tests.

“The tests showed a respiratory infection (COVID-19 infection excluded) that will require some days of medical treatment in the hospital,” Bruni’s statement said.

Francis appeared in relatively good form during his regularly scheduled general audience earlier Wednesday, though he grimaced strongly while getting in and out of the “popemobile.” He nevertheless rode around the square as usual, kissing babies and greeting the faithful.

Bruni said Francis, an Argentine Jesuit, was grateful for the prayers and messages wishing him a speedy recovery, including from the Italian bishops conference.